As aesthetic medicine evolves, many patients are moving away from treatments that simply add temporary volume and are instead looking for options that improve skin quality, collagen production, and structural support over time.
Collagen biostimulators have become increasingly popular for this reason. Rather than acting as traditional fillers, they work by encouraging the body to rebuild its own collagen.
One of the newer treatments in this category is JULÄINE, a poly-L-lactic acid (PLLA) collagen stimulator designed to gradually improve skin firmness, texture, and elasticity.
At Dr Selina Clinics in South Woodford, regenerative treatments that support the skin’s natural repair processes form an important part of a long-term approach to facial rejuvenation.
What Is JULÄINE?
JULÄINE is a collagen-stimulating injectable treatment that uses poly-L-lactic acid (PLLA) to improve skin quality and firmness.
PLLA is a biodegradable, biocompatible material that has been used safely in medicine for decades, including in dissolvable surgical sutures.
When injected into the skin, PLLA works by stimulating fibroblasts, the cells responsible for producing collagen. Over time, this encourages the skin to rebuild its structural support and improve dermal thickness.
Unlike traditional dermal fillers that provide immediate volume, JULÄINE works more gradually by stimulating collagen production within the skin itself.
How JULÄINE Works
JULÄINE contains microspheres of poly-L-lactic acid suspended in a carrier solution.
Once injected:
• the carrier fluid is absorbed by the body
• PLLA particles remain within the dermis
• these particles stimulate fibroblasts to produce new collagen
• the skin gradually becomes firmer and more resilient
Because collagen production takes time, improvements develop progressively over several weeks and months.
The result is a subtle tightening effect, improved skin texture, and smoother appearance.
Why Collagen Matters in Skin Ageing
Collagen is the main structural protein within the skin.
From our mid-twenties onwards, collagen production begins to decline. Over time this leads to:
• thinner skin
• fine lines and wrinkles
• reduced elasticity
• skin laxity
Treatments that stimulate collagen production aim to restore some of this structural support, improving the quality and strength of the skin itself.
What Makes JULÄINE Different From Other Collagen Biostimulators?
Many patients are familiar with Sculptra, another well-known PLLA collagen stimulator.
However, there are certain areas of the face where Sculptra is typically avoided because of a higher risk of nodules or uneven collagen stimulation.
JULÄINE has been designed with a refined particle suspension, which allows it to be used more safely in delicate areas that are often difficult to treat.
These areas include:
• under the eyes (tear trough area)
• nasolabial folds
• midface skin quality improvement
This makes JULÄINE particularly useful for patients who want to address early collagen loss and thinning skin in delicate facial areas.
A Regenerative Alternative for Patients Concerned About Filler Migration
Many patients are increasingly concerned about filler migration, particularly in delicate areas such as the under-eye region or around the nose and mouth.
Traditional hyaluronic acid fillers work by adding volume, but in certain areas they may move from the original injection site over time.
Collagen stimulators like JULÄINE work differently.
Instead of placing a volume-creating gel within the tissue, the treatment stimulates the body’s own collagen production, gradually improving skin thickness and support.
Because the treatment does not rely on placing large amounts of filler gel within the tissue, it can offer a more natural regenerative approach that avoids the risk of filler migration.
For patients seeking subtle rejuvenation and improved skin quality, this can be an attractive alternative.
What Areas Can JULÄINE Treat?
JULÄINE is particularly helpful for improving skin quality and collagen support in areas such as:
• under the eyes
• nasolabial folds
• cheeks
• jawline
• areas of mild skin laxity
The treatment is ideal for patients who want natural-looking improvements rather than obvious volume enhancement.
What Results Can Patients Expect?
Because JULÄINE works by stimulating collagen production, results develop gradually.
Patients may notice:
• improved skin firmness
• smoother texture
• softening of fine lines
• subtle tightening of the skin
• an overall rejuvenated appearance
Collagen continues to develop over several months, and results from PLLA-based treatments can typically last between 12 and 24 months.
How Many Treatments Are Needed?
Treatment plans are tailored to each patient.
A typical protocol involves:
• three treatment sessions
• spaced 2–4 weeks apart
This staged approach allows collagen stimulation to build gradually and ensures natural-looking results.
Who Is a Suitable Candidate for JULÄINE?
JULÄINE may be suitable for patients who:
• want gradual and natural-looking rejuvenation
• have early to moderate skin laxity
• want to improve skin quality rather than simply add volume
• are concerned about filler migration and prefer regenerative treatments
Who Should Avoid Treatment?
JULÄINE is generally not recommended for patients with:
• active skin infection or inflammation
• allergy to product components
• bleeding disorders or certain anticoagulant medications
• a history of keloid or hypertrophic scarring
• pregnancy or breastfeeding
A full consultation is essential before treatment.
Treatment Pricing at Dr Selina Clinics
At Dr Selina Clinics, JULÄINE treatments are performed following a detailed medical consultation and facial assessment.
Price: £1,200 per vial
The number of vials recommended will depend on:
• the treatment area
• degree of collagen loss
• overall skin quality
• the patient’s aesthetic goals
Because JULÄINE works gradually by stimulating collagen production, treatment plans are designed to achieve subtle, natural improvements over time.
Is JULÄINE Safe?
JULÄINE is CE-marked, meaning it meets European safety and quality standards.
PLLA has been used safely in medicine for over 40 years, with extensive clinical experience supporting its use in regenerative aesthetic treatments.
As with all injectable treatments, outcomes depend on:
• correct patient selection
• appropriate injection technique
• practitioner experience
For this reason, treatments should always be performed by qualified medical professionals with a thorough understanding of facial anatomy.
Considering JULÄINE Treatment?
If you are interested in treatments that support natural collagen regeneration, improved skin quality, and subtle rejuvenation, JULÄINE may be an appropriate option.
During your consultation at Dr Selina Clinics, we will assess:
• your skin quality and collagen loss
• your aesthetic goals
• the most appropriate treatment options for you
A personalised treatment plan can then be created to achieve natural, long-lasting results.